Tos crónica por hipersensibilidad refleja: un nuevo paradigma con implicancias diagnósticas y terapéuticas
DOI:
https://doi.org/10.22529/me.2018.3(4)05Palabras clave:
tos, hipersensibilidad, fisiopatología, antitusivosResumen
La tos es un reflejo protector del aparato respiratorio que si se prolonga en el tiempo puede afectar seriamente la calidad de vida. Recientemente un nuevo paradigma califica a la tos por hipersensibilidad refleja consecuente a una exagerada sensibilidad de las terminaciones nerviosas periféricas a diversos estímulos y a alteraciones en los núcleos centrales integradores del reflejo. Este nuevo paradigma tiene implicancias terapéuticas, más allá del tratamiento de la causa de la tos. En este artículo se revisarán los nuevos mecanismos implicados en la tos por hipersensibilidad refleja y las nuevas drogas en investigación que modulan el reflejo tusígeno. A pesar de las nuevas investigaciones farmacológicas se necesitan evidencias más seguras para aconsejar un tratamiento sintomático de estos pacientes que contribuya al control de la hipersensibilidad central y periférica del reflejo de la tos.Descargas
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