Uso racional de antihistamínicos en enfermedades alérgicas y respiratorias
DOI:
https://doi.org/10.22529/me.2023.8(4)02Parole chiave:
histamina, rinitis, anafilaxia, farmacología, efectos adversosAbstract
La histamina es el mediador químico principal producido por el mastocito ante estímulos inmunológicos y no inmunológicos que interviene en la producción de síntomas de broncoespasmos, rinitis, urticaria y anafilaxia. Los antihistamínicos H1 son fármacos ampliamente indicados por pediatras y clínicos en su práctica médica desde hace más de 50 años. El desarrollo de anti-H1 de segunda generación y sus metabolitos han contribuido a su uso más eficaz y con alta seguridad terapéutica. Este artículo tiene el objetivo revisar la farmacología e indicaciones clínicas más relevantes a fin de contribuir a la indicación adecuada y racional de los antihistamínicos H1.Downloads
Riferimenti bibliografici
Fitzsimons R, van der Poel LA, Thornhill W, du Toit G, et al. Antihistamine uses in children. Arch Dis Child Educ Pract Ed 2015;100(3):122-31. https://doi.org/10.1136/archdischild-2013-304446
Church MK, Church DS. Pharmacology of antihistamines. Indian J Dermatol 2013; 58:219-24. https://doi.org/10.4103/0019-5154.110832
Criado PR, Criado RF, Maruta CW, Machado Filho Cd. Histamine, histamine receptors and antihistamines: new concepts. Ann Bras Dermatol 2010 ;85(2):195210. https://doi.org/10.1590/S0365-05962010000200010
Miligkos M, Dakoutrou M, Statha E, Theochari NA, et al. Newergeneration antihistamines and the risk of adverse events in children: A systematic review. Pediatr Allergy Immunol 2021;32(7):1533-58. https://doi.org/10.1111/pai.13522
Del Cuvillo A, Sastre J, Montoro J, Jáuregui I, et al. Use of antihistamines in pediatrics. J Investig Allergol Clin Immunol 2007;17 (Suppl 2):28-40.
Loew ER, Macmillan R, Kaiser M. The antihistamine properties of benadryl, B- dimethylaminoethyl benzhydryl ether hydrochloride. J Pharmacol Exp Ther 1946; 86:22938. https://doi.org/10.1016/S0022-3565(25)07849-8
Emanuel MB. Histamine and the antiallergic antihistamines: a history of their discoveries. Clin Exp Allergy 1999;29 (Suppl 3):1-11. https://doi.org/10.1046/j.1365-2222.1999.00004.x-i1
Parisi GF, Leonardi S, Ciprandi G, Corsico A, et al. Antihistamines in children and adolescents: A practical update. Immunopathol 2020;48(6):753-62. Allergol (Madr) https://doi.org/10.1016/j.aller.2020.02.005
Parsons ME, Ganellin CR. Histamine and its receptors. Br J Pharmacol 2006;147 (Suppl 1): S127-S135. https://doi.org/10.1038/sj.bjp.0706440
Boyle J, Eriksson M, Stanley N, Fujita T, Kumagi Y. Allergy medication in Japanese volunteers: treatment effect of single doses on nocturnal sleep architecture and next day residual effects. Curr Med Res Opin 2006;22(7):1343-51. https://doi.org/10.1185/030079906X112660
Sateia MJ, Buysse DJ, Krystal AD, Neubauer DN, et al. Clinical Practice Guideline Pharmacologic for Treatment the of Chronic Insomnia in Adults: An American Academy of Sleep Medicine Clinical Practice Guideline. J Clin Sleep Med 2017;13(2):307-49. https://doi.org/10.5664/jcsm.6470
Sen A, Akin A, Craft KJ, Canfield DV, et al. First-generation H1 antihistamines found in pilot fatalities of civil aviation accidents, 1990-2005.Aviat Space Environ Med 2007 May;78(5):514-22.
Perttula A, Pitkäniemi J, Heinonen OP, Finkle WD, et al. Secondgeneration antihistamines exhibit a protective effect on drivers in traffic-a preliminary populationbased case-control study. Traffic Inj Prev 2014;15(6):551-5. https://doi.org/10.1080/15389588.2013.861597
Walker S, Khan-Wasti S, Fletcher M, Cullinan P, et al. Seasonal allergic rhinitis is associated with a detrimental effect on examination performance in United Kingdom teenagers: case-control study. J Allergy Clin Immunol 2007;120(2):381-7. https://doi.org/10.1016/j.jaci.2007.03.034
Vuurman EFPM, van Veggel LMA, Uiterwijk MMC, Leutner D, et al. Seasonal allergic rhinitis and antihistamine effects on children's learning. Ann Allergy 1993; 71:121-6.
Suessbrich H, Waldegger S, Lang F, Busch AE. Blockade of HERG channels expressed in Xenopus oocytes by the histamine receptor antagonists terfenadine and astemizole. FEBS Lett 1996; 385:77-80. https://doi.org/10.1016/0014-5793(96)00355-9
Fasano PA. Antihistamínicos. Parte II - ¿Cuáles son las opciones y en qué basarse para elegir la mejor? Arch Alergia e Inmunol Clin 2013;44(3):76-84.
Delgado LF, Pferferman A, Solé D, Naspitz CK. Evaluation of the potential cardiotoxicity of the antihistamines terfenadine, astemizol, loratadine and cetirizine in atopic children. Ann Allergy Asthma Immunol 1998; 80:333-37. https://doi.org/10.1016/S1081-1206(10)62979-1
Graft DF, Bernstein DL, Goldsobel A, Meltzer EO, et al. Safety of fexofenadine in children treated for seasonal allergic rhinitis. Ann Allergy Asthma Immunol 2001;87: 22-26. https://doi.org/10.1016/S1081-1206(10)62317-4
Ramachandran K, Sirop P. Rare complications of diphenhydramine toxicity. Conn Med 2008;72: 79-82.
Goetz CM, Lopez G, Dean BS, Krenzelok EP. childhood death Accidental from diphenhydramine overdosage. Am J Emerg Med 1990;8: 321-22. https://doi.org/10.1016/0735-6757(90)90085-E
Baker AM, Johnson DG, Levisky JA, Hearn WL, et al. Fatal diphenhydramine intoxication in infants. J Forensic Sci 2003;48: 4258. https://doi.org/10.1520/JFS2002121
Pragst F, Herre S, Bakdash A. Poisonings with diphenhydramine - a survey of 68 clinical and 55 death cases. Forensic Sci Int 2006;161: 189-97. https://doi.org/10.1016/j.forsciint.2006.01.019
Church MK, Maurer M, Simons FE, Bindslev-Jensen C, et al. Global Allergy and Asthma European Network. Risk of first-generation H (1)-antihistamines: a GA(2)LEN position paper. Allergy 2010;65(4):459-66. https://doi.org/10.1111/j.1398-9995.2009.02325.x
Holgate ST, Canonica GW, Simons FE, Taglialatela M, et al. Consensus Group on New-Generation Antihistamines (CONGA): present status and recommendations. Clin Exp Allergy 2003;33(9):1305-24. https://doi.org/10.1046/j.1365-2222.2003.01769.x
Mandola A, Nozawa A, Eiwegger T. Histamine, histamine receptors, and antihistamines in the context of allergic responses. LymphoSign J 2019;6: 35-51. https://doi.org/10.14785/lymphosign-2018-0016
Tiligada E, Ennis M. Histamine pharmacology: from Sir Henry Dale to the 21st century. Br J Pharmacol 2020;177(3):469-89. https://doi.org/10.1111/bph.14524
Simons FE, Simons KJ. Histamine and H1-antihistamines: celebrating a century of progress. J Allergy Clin Immunol 2011; 128:1139-50. e4. https://doi.org/10.1016/j.jaci.2011.09.005
Brozek JL, Bousquet J, BaenaCagnani CE, et al. Allergic Rhinitis and its Impact on Asthma (ARIA) guidelines: 2010 revision. J Allergy Clin Immunol 2010; 126:466-76. https://doi.org/10.1016/j.jaci.2010.06.047
Comité Nacional de Alergia, Comité Nacional de Neumonología y Comité de Otorrinolaringología de SAP Filial Córdoba. Consenso Nacional de Rinitis Alérgica en Pediatría. Arch Argent Pediatr 2009;107(1):67-81.
Ratner PH, Hampel F, Van BJ, et al. Combination therapy with azelastine hydrochloride nasal spray and fluticasone propionate nasal spray in the treatment of patients with seasonal allergic rhinitis. Ann Allergy Asthma Immunol 2008; 100:74-81. https://doi.org/10.1016/S1081-1206(10)60408-5
Comité Nacional de Alergia. Recomendaciones para el diagnóstico y tratamiento de la urticaria en pediatría. Arch Argent Pediatr 2021;119(2): S54-S66. https://doi.org/10.5546/aap.2021.s54
Comité Nacional de Dermatología. Consenso Nacional de Dermatitis Atópica 2013: resumen ejecutivo. Arch Argent Pediatr 2014;112(3):293-4.
Atopic eczema in under 12s: diagnosis and management. London: National Institute for Health and Care Excellence (NICE); 2021 Mar 2.
Parisi GF, Licari A, Papale M, Manti S, et al. Antihistamines: ABC for the pediatricians. Pediatr Allergy Immunol. 2020 ;31 Suppl 24:34-36. https://doi.org/10.1111/pai.13152
Saranz RJ, Lozano A, Lozano NA, Ponzio MF, et al Subclinical lower airways correlates of chronic allergic and non-allergic rhinitis. Clin Exp Allergy 2017;47(8):98897. https://doi.org/10.1111/cea.12938
Agresta MF, Saranz RJ, Lozano NA, Lozano A. Relación entre rinitis y asma: ¿está todo dicho? Rev Fac Cien Med Univ Nac Cordoba 2014;71(2):111-21. https://doi.org/10.31053/1853.0605.v71.n2.9081
Poowuttikul P, Seth D. Anaphylaxis in children and adolescents. Pediatr Clin North Am 2019;66(5):9951005. https://doi.org/10.1016/j.pcl.2019.06.005
Sheikh A, Ten Broek V, Brown SG, Simons FE. H1-antihistamines for the treatment Cochrane of anaphylaxis: systematic review. Allergy 2007; 62:830. https://doi.org/10.1111/j.1398-9995.2007.01435.x
Saranz RJ, Lozano A, Lozano NA, Castro Rodríguez JA. Diagnóstico y tratamiento de la tos crónica en pediatría. Arch Argent Pediatr 2013;111(2):140-7. https://doi.org/10.5546/aap.2013.140
Gray SL, Anderson ML, Dublin S, Hanlon JT, et al. Cumulative use of strong anticholinergics and incident dementia: a prospective cohort study. JAMA Intern Med 2015;175: 401-7. https://doi.org/10.1001/jamainternmed.2014.7663
Alfabeta.net. Manual farmacéutico. Edición Argentina. Precios de los medicamentos. Disponible en https://alfabeta.net/precio/ [ ultima consulta: 30 de noviembre de 2022].
Ministerio de Salud. República Argentina. Plan Remediar: Guía de medicamentos esenciales en el primer nivel de atención. Disponible en https://www.argentina.gob.ar/salud/ remediar [ultima consulta: 30 de noviembre de 2022].
PAMI. INSSJP. Principios activos incluidos en el nuevo Vademécum PAMI. Disponible en https://www.pami.org.ar/pdf/nuevo _vademecum_pami.pdf [ ultima consulta: 30 de noviembre de 2022].
