Oseointegración, aspectos que determinan su éxito. Revisión de la literatura
DOI:
https://doi.org/10.22529/me.2020.5(4)07Palavras-chave:
oseointegración, implante dental, superficie, diseñoResumo
El éxito del implante dental depende en gran medida de las características químicas, físicas, mecánicas y topográficas de su superficie; ya que determinan la actividad de las células que se adhieren a la superficie del implante. Por lo tanto, la humectabilidad, geometría, topografía, rugosidad, energía superficial, nanoestructuras y el recubrimiento con materiales bioactivos tienen un impacto sustancial en el éxito y calidad del proceso de oseointegración. Metodología: Se realizó una revisión de la literatura mediante la base de datos de MedLine con el motor de búsqueda Pubmed. Se seleccionaron, una vez aplicados los criterios de inclusión y exclusión, un total de 69 artículos. Resultados: La combinación de estas propiedades determinan la calidad y grado de oseointegración. Valores moderados de hidrofilia (30?-60?) y rugosidad (Sa=1-2?m) favorecen la oseointegración, pero aún se desconocen los mecanismos biológicos subyacentes. La investigación actual sigue los enfoques biomiméticos: imitar la configuración 3D de la superficie ósea.Downloads
Referências
Buser D, Mericske-Stern RD, Bernard JP. Long-term evaluation of non-submerged ITI implants. Part 1: 8-year life table analysis of a prospective multi-center study with 2359 implants. Clin Oral Impl Res 1997; 8: 161-72. https://doi.org/10.1034/j.1600-0501.1997.080302.x
Albrektsson, T.; Chrcanovic, B.; Molne, J.; Wennerberg, A. Foreign body reactions,marginal bone loss and allergies in relation to titanium implants. Eur. J. Oral Implantol.2018, 11, S37-S46.
Coelho PG, Jimbo R, Tovar N, Bonfante EA. Osseointegration: hierarchicaldesigning encompassing the macrometer, micrometer, and nanometer length scales.Dent Mater. 2015 Jan;31(1):37-52. https://doi.org/10.1016/j.dental.2014.10.007
Salvi GE, Bosshardt DD, Lang NP, Abrahamsson I, et al. Temporal sequence of hardand soft tissue healing around titanium dental implants. Periodontol 2000. 2015Jun;68(1):135-52. https://doi.org/10.1111/prd.12054
Meng H-W, Chien EY, Chien H-H. Dental implant bioactive surface modifications and their effects on osseointegration: a review. Biomark Res. 2016;4(Dec 14):24. https://doi.org/10.1186/s40364-016-0078-z
Ogle OE. Implant surface material, design, and osseointegration. Dent Clin NorthAm. 2015 Apr;59(2):505-20. https://doi.org/10.1016/j.cden.2014.12.003
Albertini M, Fernandez-Yague M, Lázaro P, Herrero-Climent M, et al. Advances in surfaces and osseointegration in implantology. Biomimetic surfaces. Med Oral Patol Oral Cir Bucal. 2015 May 1;20(3):31625. https://doi.org/10.4317/medoral.20353
Adell R, Lekholm U, Rockler B, Branemark PI. 15-year study of osseointegrated implants in the treatment of the edentulous jaw. Int. J. Oral Surg. 1981; 10: 387-416. https://doi.org/10.1016/S0300-9785(81)80077-4
Branemark R, Branemark PI, Rydevik B, Myers R. Osseointegration in skeletal reconstruction and rehabilitation. A review. J. Rehab. Reseach Dev. 2001; 38 (2): 175-181.
Feller L, Jadwat Y, Khammissa RAG, Meyerov R, et al. Cellular responses evokedby different surface characteristics of intraosseous titanium implants. Biomed Res Int.2015; 2015:171945. https://doi.org/10.1155/2015/171945
Annunziata M, Guida L. The Effect of Titanium Surface Modifications on DentalImplant Osseointegration. Front Oral Biol. 2015; 17:62-77. https://doi.org/10.1159/000381694
Velasco-Ortega E, Alfonso-Rodríguez CA, Monsalve-Guil L, España-López JiménezGuerra A, et al. Relevant aspects in the surface properties in titanium dentalimplants for the cellular viability. Mater Sci Eng C Mater Biol Appl. 2016 Jul 1;64(Jul1):1-10. https://doi.org/10.1016/j.msec.2016.03.049
Liu P, Hao Y, Zhao Y, Yuan Z, et al. Surface modification of titanium substrates for enhanced osteogenetic and antibacterial properties. Colloids Surf B Biointerfaces. 2017 Dec 1;160(Dec 1):110-6 https://doi.org/10.1016/j.colsurfb.2017.08.044
Andrukhov O, Huber R, Shi B, Berner S, Rausch-Fan X, et al. Proliferation, behavior, and differentiation of osteoblasts on surfaces of different microroughness. Dent Mater. 2016 Nov;32(11):1374-84. https://doi.org/10.1016/j.dental.2016.08.217
Sul Y-T, Kang B-S, Johansson C, Um H-S, et al. The roles of surface chemistry and topography in the strength and rate of osseointegration of titanium implants in bone. J Biomed Mater Res A. 2009 Jun 15;89(4):942-50. https://doi.org/10.1002/jbm.a.32041
Schmid J, Brunold S, Bertl M, Ulmer H, Kuhn V, et al. Biofunctionalization of onplants to enhance their osseointegration. Int J Stomatol Occlusion Med. 2014 Dec 5;7(4):105-10. https://doi.org/10.1007/s12548-014-0116-0
Bressan E, Sbricoli L, Guazzo R, Tocco I, et al. Nanostructured surfaces of dental implants. Int J Mol Sci. 2013 Jan 17;14(1):1918-31. https://doi.org/10.3390/ijms14011918
Shibata Y, Tanimoto Y, Maruyama N, Nagakura M. A review of improved fixation methods for dental implants. Part II: biomechanical integrity at bone-implant interface. J Prosthodont Res. 2015 Apr;59(2):84-95. https://doi.org/10.1016/j.jpor.2015.01.003
von Wilmowsky C, Moest T, Nkenke E, Stelzle F, et al. Implants in bone: part I. A current overview about tissue response, surface modifications and future perspectives. Oral Maxillofac Surg. 2014 Sep;18(3):24357. https://doi.org/10.1007/s10006-013-0398-1
Olivares-Navarrete R, Hyzy SL, Berg ME, Schneider JM, et al. Osteoblast lineage cells can discriminate microscale topographic features on titanium-aluminum-vanadium surfaces. Ann Biomed Eng. 2014 Dec;42(12):2551-61. https://doi.org/10.1007/s10439-014-1108-3
Smeets R, Stadlinger B, Schwarz F, BeckBroichsitter B, et al. Impact of Dental Implant Surface Modifications on Osseointegration. Biomed Res Int. 2016; 2016:6285620. https://doi.org/10.1155/2016/6285620
Dohan Ehrenfest DM, Coelho PG, Kang B-S, Sul Y-T, et al. Classification of osseointegrated implant surfaces: materials, chemistry and topography. Trends Biotechnol. 2010 Apr;28(4):198-206. https://doi.org/10.1016/j.tibtech.2009.12.003
Buser, D.; Janner, S.F.; Wittneben, J.G.; Bragger, U.; et al. 10-year survival and success rates of 511 titanium implants with a sandblasted and acid-etched surface: A retrospective study in 303partially edentulous patients. Clin. Implant Dent. Relat. Res. 2012; 14: 839-851 https://doi.org/10.1111/j.1708-8208.2012.00456.x
Rupp F, Liang L, Geis-Gerstorfer J, Scheideler L, et al. Surface characteristics of dental implants: A review. Dent Mater. 2018 Jan;34(1):40-57. https://doi.org/10.1016/j.dental.2017.09.007
Shibata Y, Tanimoto Y. A review of improved fixation methods for dental implants. Part I: Surface optimization for rapid osseointegration. J Prosthodont Res. 2015 Jan;59(1):20-33. https://doi.org/10.1016/j.jpor.2014.11.007
Olivares-Navarrete R, Rodil SE, Hyzy SL, Dunn GR, et al. Role of integrin subunits in mesenchymal stem cell differentiation and osteoblast maturation on graphitic carboncoated microstructured surfaces. Biomaterials. 2015 May; 51:69-79. https://doi.org/10.1016/j.biomaterials.2015.01.035
Hotchkiss KM, Reddy GB, Hyzy SL, Schwartz Z, et al. Titanium surface characteristics, including topography and wettability, alter macrophage activation. Acta Biomater. 2016 Feb;31(Feb):425-34. https://doi.org/10.1016/j.actbio.2015.12.003
Gittens RA, Scheideler L, Rupp F, Hyzy SL, et al. A review on the wettability of dental implant surfaces II: Biological and clinical aspects. Acta Biomater. 2014 Jul;10(7):290718.https://doi.org/10.1016/j.actbio.2014.03.032
Livne S, Marku-Cohen S, Harel N, Piek D, et al. [The influence of dental implant surface on osseointegration: review]. Refuat Hapeh Vehashinayim. 2012 Jan;29(1):41-6, 66.
Rupp F, Gittens RA, Scheideler L, Marmur A, et al. A review on the wettability of dental implant surfaces I: theoretical and experimental aspects. Acta Biomater. 2014 Jul;10(7):2894-906. al. https://doi.org/10.1016/j.actbio.2014.02.040
Pegueroles M, Aparicio C, Bosio M, Engel E, et Spatialorganization of osteoblast fibronectin matrix on titanium surfaces: effects of roughness, chemical heterogeneity and surface energy. Acta Biomater. 2010 Jan;6(1):291-301. https://doi.org/10.1016/j.actbio.2009.07.030
Gittens RA, Olivares-Navarrete R, Cheng A, Anderson DM, et al. The roles of titanium surface micro/nanotopography and wettability on the differential response of human osteoblast lineage cells. Acta Biomater. 2013 Apr;9(4):6268-77. https://doi.org/10.1016/j.actbio.2012.12.002
Chan KH, Zhuo S, Ni M. Priming the Surface of Orthopedic Implants for Osteoblast Attachment in Bone Tissue Engineering. Int J Med Sci. 2015;12(9):701-7. https://doi.org/10.7150/ijms.12658
Gittens RA, Olivares-Navarrete R, Schwartz Z, Boyan BD. Implant osseointegration and the role of microroughness and nanostructures: lessons for spine implants. Acta Biomater. 2014 Aug;10(8):3363-71 https://doi.org/10.1016/j.actbio.2014.03.037
Jemat A, Ghazali MJ, Razali M, Otsuka Y. Surface Modifications and Their Effects on Titanium Dental Implants. Biomed Res Int. 2015; 2015:791725. https://doi.org/10.1155/2015/791725
Barfeie A, Wilson J, Rees J. Implant surface characteristics and their effect on osseointegration. Br Dent J. 2015 Mar 13;218(5). https://doi.org/10.1038/sj.bdj.2015.171
Tobin EJ. Recent coating developments for combination devices in orthopedic and dental applications: A literature review. Adv Drug Deliv Rev. 2017 Mar;112(Mar):88- 100. https://doi.org/10.1016/j.addr.2017.01.007
Compton JT, Lee FY. A review of osteocyte function and the emerging importance of sclerostin. J Bone Joint Surg Am. 2014 Oct 1;96(19):1659-68. https://doi.org/10.2106/JBJS.M.01096
Virdi AS, Irish J, Sena K, Liu M, et al. Sclerostin antibody treatment improves implant fixation in a model of severe osteoporosis. J Bone Joint Surg Am. 2015 Jan 21;97(2):133-40. https://doi.org/10.2106/JBJS.N.00654
Stadlinger B, Korn P, Tödtmann N, Eckelt U, et al. Osseointegration of biochemically modified implants in an osteoporosis rodent model. Eur Cell Mater. 2013 Jul 8; 25:326-4040. https://doi.org/10.22203/eCM.v025a23
Ferraris S, Spriano S. Antibacterial titanium surfaces for medical implants. Mater Sci Eng C Mater Biol Appl. 2016 Apr 1;61(1):965-78. https://doi.org/10.1016/j.msec.2015.12.062
Rivera-Chacon DM, Alvarado-Velez M, Acevedo-Morantes CY, Singh SP, et al. Fibronectin and vitronectin promote human fetal osteoblast cell attachment and proliferation on nanoporous titanium surfaces. J Biomed Nanotechnol. 2013 Jun;9(6):10927. https://doi.org/10.1166/jbn.2013.1601
Trindade R, Albrektsson T, Galli S, Prgomet Z, et al. Osseointegration and foreign body reaction: titanium implants activate the immune system and suppress bone resorption during the first 4 weeks after implantation. Clin Implant Dent Relat Res. 2018; 20:82-91 https://doi.org/10.1111/cid.12578
Albrektsson T, Chrcanovic B, Jacobsson M, Wennerberg A. Osseointegration of implants-a biological and clinical overview. JSM Dent Surg. 2017; 2:1-6.
Van Velzen, F.J.; Ofec, R.; Schulten, E.A.; Ten Bruggenkate, C.M. 10-year survival rate and the incidence of peri-implant disease of 374 titanium dental implants with a SLA surface: A prospective cohort study in 177 fully and partially edentulous patients. Clin. Oral Implants Res. 2015; 26: 1121-1128. https://doi.org/10.1111/clr.12499
Wheelis SE, Montaño-Figueroa AG, Quevedo-Lopez M, Rodrigues DC. Effects of titanium oxide surface properties on boneforming and soft tissue-forming cells. Clin Implant Dent Relat Res. 2018;20(5): 838-847. https://doi.org/10.1111/cid.12656
Ramaglia L, Postiglione L, Di Spigna G, Capece G, et al. Sandblastedacid- etched titanium surface influences in vitro the biological behavior of SaOS-2 human osteoblast-like cells. Dent Mater J. 2011;30(2):183-92. https://doi.org/10.4012/dmj.2010-107
Albrektsson, T., & Wennerberg, A. On osseointegration in relation to implant surfaces. Clinical Implant Dentistry and Related Research. 2019; 21(1):4-7 https://doi.org/10.1111/cid.12742
Al Mustafa M, Agis H, Müller HD, Watzek G, et al. In vitro adhesion of fibroblastic cells to titanium alloy discs treated with sodium hydroxide. Clin Oral Implants Res. 2015;26(1):15-19. https://doi.org/10.1111/clr.12294
Yamamura K, Miura T, Kou I, Muramatsu T, et al. Influence of various superhydrophilic treatments of titanium on the initial attachment, proliferation, and differentiation of osteo-blast-like cells. Dent Mater J. 2015;34(1):120-127. https://doi.org/10.4012/dmj.2014-076
Lang NP, Salvi GE, Huynh-Ba G, Ivanovski S, et al. Early osseointegration to hydrophilic and hydrophobic implant surfaces in humans. Clin Oral Implants Res. 2011; 22:349-356. https://doi.org/10.1111/j.1600-0501.2011.02172.x
Yeo, I.S.; Min, S.K.; Kang, H.K.; Kwon, T.K, et al. Identification of a bioactive core sequence from human laminin and its applicability to tissue engineering. Biomaterials 2015; 73: 96-109. https://doi.org/10.1016/j.biomaterials.2015.09.004
Pjetursson BE, Thoma D, Jung R, Zwahlen M, et al. A systematic review of the survival and complication rates of implant-supported fixed dental prostheses (FDPs) after a mean observation period of at least 5 years. Clin Oral Implants Res. 2012 Oct;23 Suppl 6:2238. https://doi.org/10.1111/j.1600-0501.2012.02546.x
Wennerberg A, Albrektsson T. Effects of titanium surface topography on bone integration: a systematic review. Clin Oral Implants Res. 2009 Sep;20 Suppl 4(Sept):172-84. https://doi.org/10.1111/j.1600-0501.2009.01775.x
Velasco E, Jos A, Pato J, Camean A, et al. In vitro evaluation of citotoxicity and genotoxixity of comercial titanium alloy for dental implantología. Mutation Res 2010; 702:17-23 https://doi.org/10.1016/j.mrgentox.2010.06.013
Oztel, M.; Bilski, W.M.; Bilski, A. Risk factors associated with dental implant failure: A study of 302 implants placed in a regional center. J. Contemp. Dent. Pract. 2017: 18: 705-709. https://doi.org/10.5005/jp-journals-10024-2111
Asensio, G.; Vazquez-Lasa, B.; Rojo, L. Achievements in the Topographic Design of Commercial Titanium Dental Implants: Towards Anti-Peri-Implantitis Surfaces. J. Clin. Med. 2019; 8: 1982. https://doi.org/10.3390/jcm8111982
Nicolau, P.; Guerra, F.; Reis, R.; Krafft, T, et al. 10-year outcomes with immediate and early loaded implants with a chemically modified SLA surface. Quintessence Int. 2018; 50: 2-12.
Ahn, T.K.; Lee, D.H.; Kim, T.S.; Jang, G.C, et al. Modification of Titanium Implant and Titanium Dioxide for Bone Tissue Engineering. Adv. Exp. Med. Biol. 2018; 1077: 355-368. https://doi.org/10.1007/978-981-13-0947-2_19
Souza, J.C.M.; Sordi, M.B.; Kanazawa, M.; Ravindran, S, et al. Nano-scale modification of titanium implant surfaces to enhance osseointegration. Acta Biomater. 2019; 94: 112-131. https://doi.org/10.1016/j.actbio.2019.05.045
Joos U, Wiesmann HP, Szuwart T, Meyer U. Mineralization at the interface of implants. Int. J. Oral Maxillofac. Surg. 2006; 35: 783790. https://doi.org/10.1016/j.ijom.2006.03.013
Abuhussein H, Pagni G, Rebaudi A, Wang HL. The effect of thread pattern upon implant osseointegration. Clin Oral Implants Res. 2010 Feb;21(2):129-36. https://doi.org/10.1111/j.1600-0501.2009.01800.x
Kim, S.; Choi, J.Y.; Jung, S.Y.; Kang, H.K, et al. A laminin-derived functional peptide, PPFEGCIWN, promotes bone formation on sandblasted, large-grit, acid-etched titanium implant surfaces. Int. J. Oral Maxillofac. Implants. 2019, 34, 836-844 https://doi.org/10.11607/jomi.7178
Albrektsson T, Berglundh T, Lindhe J. Osseointegration: Historic background and current concepts. En: Lindhe J, Karring T, Lang N, eds. Clinical Periodontology and Implant Dentistry. Blackwell Munksgaard, 2003: 809-820.
Albrektsson T, Chrcanovic B, Jacobsson M, Wennerberg A. Osseointegration of implants-a biological and clinical overview. JSM Dent Surg. 2017; 2:1-6.
Le Guéhennec L, Soueidan A, Layrolle P, Amouriq Y. Surface treatments of titanium dental implants for rapid osseointegration. Dent Mater. 2007 Jul;23(7):844-54. https://doi.org/10.1016/j.dental.2006.06.025
Avila G, Misch K, Galindo-Moreno P, Wang H-L. Implant surface treatment using biomimetic agents. Implant Dent. 2009 Feb;18(1):17-26. https://doi.org/10.1097/ID.0b013e318192cb7d
Thakral G, Thakral R, Sharma N, Seth J, et al. Nanosurface - the future of implants. J Clin Diagn Res. 2014 May;8(5): ZE07-10. https://doi.org/10.7860/JCDR/2014/8764.4355
Ogawa T. Ultraviolet photofunctionalization of titanium implants. Int J Oral Maxillofac Implants. 2014;29(1): e95-e102. https://doi.org/10.11607/jomi.te47
