Nanotecnología en Odontología: Aspectos generales y posibles aplicaciones
DOI:
https://doi.org/10.22529/me.2018.3(3)03Parole chiave:
nanotecnología, materiales dentales, innovaciones tecnológicasAbstract
Las innovaciones tecnológicas en Odontología procuran desde las Nanociencias dar solución a una diversidad de problemas en el cuidado de la salud bucal. La obtención de partículas a escala atómica se logra por dos vías: reduciendo una partícula hasta lograr un tamaño nanométrico o ensamblando nanoelementos con características y propiedades específicas. Estos pequeños compuestos tienen potenciales aplicaciones en el diagnóstico, prevención y tratamiento de patologías orales desde caries, enfermedad periodontal, maloclusiones, lesiones en tejidos blandos y hasta posibles indicaciones para mejorar la estética dental y el comportamiento mecánico, biológico y óptico de materiales restauradores. Algunos desarrollos se encuentran consolidados con etapas exitosas de experimentación y aplicación clínica en tanto que otros se avizoran con expectativas de cambios revolucionarios, como aquellas relacionadas a la ingeniería tisular.Downloads
Riferimenti bibliografici
Cantín M, Vilos C, Suazo I. Nanoodontología: el Futuro de Odontología Basada en Sistemas Nanotecnológicos. Int J Odontostomat, 4(2):127-132, 2010. https://doi.org/10.4067/S0718-381X2010000200005
Nagpal A, Kaur J, Sharma S, BansalA, Sachdev P. Nanotechnology-the Era of MolecularDentistry. Indian J DentSci 2011;3: 80-2.
Freitas RA Jr. Nanodentistry. J Am DentAssoc 2000;131(11):1559-65. https://doi.org/10.14219/jada.archive.2000.0084
Kanaparthy R, Kanaparthy A. Thechangingface of dentistry: nanotechnology. Int J Nanomed 2011;6;2799-804.
https://doi.org/10.2147/IJN.S24353
Chen F, Cai W, eds. HybridNanomaterials. Design, Synthesis, and BiomedicalApplications, CRC Press, Taylor and Francis Group, Boca Raton, Florida, 2017.
Silva GA. Neurosciencena notechnology: progress, opportunities and challenges. NatRevNeurosci. 2006; 7:65-74.
https://doi.org/10.1038/nrn1827
Zhang S. Fabrication of novel biomaterialsthrough molecular self-assembly. NatBiotechnol. 2003; 21:1171-1178.
https://doi.org/10.1038/nbt874
Mihranyan A, Ferraz N, Strømme M. Current status and futureprospects of nanotechnology in cosmetics. Prog Mater Sci 2012,57:875- 910. https://doi.org/10.1016/j.pmatsci.2011.10.001
Gazzaniga G, RoveriN, Rimondini L, Palazzo B, Lafisco M. Biologically active nanoparticles of a carbonatesubstitutedhydroxyapatitteprocessfortheirpre paration and composition sincorporating thesame. 2007 WO137606A1.
Henkel AAK, Suthech GMBH Co. KG, Barth A, Kropf C, Poth T. Oral and dental careproduct. 2005, WO020878A2.
Chen FM, An Y, Zhang M. New insightsinto and novel applications of releas etechnologyfor periodontal reconstructive therapies. J Control Release 2011,149:92-110. https://doi.org/10.1016/j.jconrel.2010.10.021
Xu HHK, Weir MD, Sun L, Moreau JL, Takagi S, Chow LC, Antonucci JM. Strongnano compositeswith Ca, PO4, and F releasefor caries inhibition. J Dent Res 2010,89:19-28. https://doi.org/10.1177/0022034509351969
Jain N, Jain GK, Javed S, Iqbal Z, Talegaonkar S, Ahmad FJ, Khar RK. Recentapproachesforthetreatment of periodontitis. DrugDiscovToday 2008,13:932-943. https://doi.org/10.1016/j.drudis.2008.07.010
Kashi TSJ, Eskandarion S, EsfandyariManesh M, Marashi SMA, Samadi N, Fatemi SM, Atyabi F, Eshraghi S, Dinarvand R. Improveddrugloading and antibacterialactivity of minocycline-loaded PLGA nanoparticlespreparedbysolid/oil/water ion pairingmethod. Int J Nanomed 2012,7:221- 234. https://doi.org/10.2147/IJN.S27709
Bhardwaj A, Bhardwaj, SV, Pandey R. Advances in periodontal drugdeliverysystems.Int J Novel DrugDelivTech 2012,2:271-275. https://doi.org/10.5005/jp-journals-10026-1034
Ganem-Quintanar A. Étude de la permeábilité de la muqueuseorale: évaluation de différentesapproachespouraugmenter le passage des principesactifs, Ph.D. thesis, Universite' de Geneve, Universite' Claude Bernard, Lyon, Genéve, 1997.
Kong, L.X., Peng, Z. Li, S.D., Bartold, P.M. Nanotechnology and its role in themanagement of periodontal diseases. Periodontology2006; 40:184-196. https://doi.org/10.1111/j.1600-0757.2005.00143.x
García-Contreras R, Argueta-Figueroa L, Mejía-Ruvalcava C, Jiménez-Martínez R, Cuevas Guajardo S, Sánchez-Reyna PA, Mendieta-Zeron H. Perspectivesforthe use of silvernanoparticles in dental practice. IntDent J 2011,61:297-301.
https://doi.org/10.1111/j.1875-595X.2011.00072.x
Monteiro DR, Gorup LF, TakamiyaAS, Rodríguez de Camargo E, FilhoACR, Barbosa DB. Silver distribution and reléase from anntimicrobialdenture base resincontainingsilverlloidalnanoparticles. J Prosthodont 2012,21:7-15.
https://doi.org/10.1111/j.1532-849X.2011.00772.x
Lansdown AB. Silver 2: Toxicity in mammals and howitsproductsaidwoundrepair. J Wound Care 2002,11:173 -177. https://doi.org/10.12968/jowc.2002.11.5.26398
Lansdown AB. Silver I: Itsantibacterialproperties and mechanism of action. J WoundCare 2002,11:125 - 130. https://doi.org/10.12968/jowc.2002.11.4.26389
Jain KK. Nanodiagnostics: application of nanotechnology in molecular diagnostics. ExpertRev Mol Diagn2003; 3:153 - 61. https://doi.org/10.1586/14737159.3.2.153
Goverdhana S, Puntel M, Xiong W, Zirger JM, Barcia C, Curtin JF, et al. Regulable gene expressionsystemsfor gene therapyapplications: progress and futurechallenges. Mol Ther 2005;12(2):189- 211. https://doi.org/10.1016/j.ymthe.2005.03.022
International Associationfor Dental Research. Launching a dental materialsresearch agenda [Internet]. Alexandria: TheAssociation; 2012 [cited 2013 Jan 14]. Availablefrom: http://www.iadr.org/files/public/13DMIW_S ummary.pdf
Sidhu SK, Nicholson JW. A Review of GlassIonomerCementsforClinicalDentistry. J FunctBiomater. 2016 Jun 28;7(3). pii: E16. https://doi.org/10.3390/jfb7030016
Baig MS, Fleming GJ. Conventionalglassionomermaterials: A review of thedevelopments in glasspowder, polyacidliquid and thestrategies of reinforcement. J Dent. 2015, Aug;43(8):897- 912. https://doi.org/10.1016/j.jdent.2015.04.004
Molina GF, Cabral RJ, Mazzola I, Brain L, Frencken JE. Mechanical performance of encapsulatedrestorativeglassionomercementsfor use withAtraumaticRestorativeTreatment (ART). J Appl Oral Sci 2013; 21(3):243-249. https://doi.org/10.1590/1679-775720130129
Najeeb S, Khurshid Z, Zafar MS, Khan AS, Zohaib S, Martí JM, Sauro S, Matinlinna JP, Rehman IU. Modifications in Glass Ionomer Cements: Nano-SizedFillers and BioactiveNanoceramics. Int J Mol Sci. 2016 Jul 14;17(7). pii: E1134. https://doi.org/10.3390/ijms17071134
Beun S, Glorieux T, Devaux J, Vreven J, Leloup G. Characterization of nanofilledcompared to universal and microfilledcomposites. Dent Mater 2007;23(1):51-9. https://doi.org/10.1016/j.dental.2005.12.003
Osorio R, Cabello I, Medina-Castillo AL, Osorio E, Toledano M. Zincmodifiednanopolymersimprovethequality of resin-dentinbonded interfaces. Clin Oral Investig. 2016 Dec;20(9):2411-2420. https://doi.org/10.1007/s00784-016-1738-y
Vollath D. Nanoparticles - Nanocomposites - Nanomateriales. An Introduction for Beginners, WILEY VCH Verlag GmbH & Co, Weinheim, Germany, 2013.
Chen HF, Clarkson BH, Sunk, Mansfield JF. Self Assembly of synthetichydroxyapatitenanorodsintoenamelp rismlikestructure. J Colloid Interface Sci 2005;288(1):97-103. https://doi.org/10.1016/j.jcis.2005.02.064
Lin LM, Ricucci D, Huang GT. Regeneration of thedentinepulpcomplexwithrevitalization/revascularizat iontherapy: challenges and hopes. IntEndod J. 2014 Aug;47(8):713-24. https://doi.org/10.1111/iej.12210
Le Gu'ehennec L, Soueidan A, Layrolle P, Amouriq Y. Surface treatments of titanium dental implants forrapidosseointegration, Dent Mater 2007;23(7):844-54. https://doi.org/10.1016/j.dental.2006.06.025
